LMPD Database

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LMP013378

UniProt Annotations

Entry Information
Gene Namephosphatidylserine synthase 1
Protein EntryPTSS1_RAT
UniProt IDQ5PQL5
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityL-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
FunctionCatalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity)
PathwayPhospholipid metabolism; phosphatidylserine biosynthesis.
SimilarityBelongs to the phosphatidyl serine synthase family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . Note=Highly enriched in the mitochondria-associated membrane (MAM)