LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP013282

UniProt Annotations

Entry Information
Gene Nameinositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein EntryIPPK_RAT
UniProt IDQ5PXE9
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate
DomainThe EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
FunctionPhosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis
SimilarityBelongs to the IPK1 type 2 family
Subcellular LocationCytoplasm . Nucleus .