LMPD Database

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LMP013147

UniProt Annotations

Entry Information
Gene NameN-acyl phosphatidylethanolamine phospholipase D
Protein EntryNAPEP_RAT
UniProt IDQ769K2
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAn N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 or 2 zinc ions per subunit. ;
Enzyme RegulationActivity is stimulated by divalent cations
FunctionHydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. {ECO:0000269|PubMed:14634025, ECO:0000269|PubMed:16527816}.
SimilarityBelongs to the NAPE-PLD family
Subcellular LocationMembrane .
SubunitMonomer. {ECO:0000269|PubMed:14634025, ECO:0000269|PubMed:16527816}.