LMPD Database

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LMP013088

UniProt Annotations

Entry Information
Gene NameSH3-domain GRB2-like endophilin B1
Protein EntrySHLB1_RAT
UniProt IDQ6AYE2
SpeciesRat
Comments
Comment typeDescription
DomainAn N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes
FunctionMay be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity)
PtmPhosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization
SimilarityBelongs to the endophilin family
SimilarityContains 1 BAR domain. {ECO:0000255|PROSITE- ProRule:PRU00361}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371}; Peripheral membrane protein . Note=Association with the Golgi apparatus depends on the cell type. {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371, ECO:0000269|PubMed:11604418}.
SubunitHomodimer, and heterodimer with SH3GLB2. Binds BAX. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity)
Tissue SpecificityExpressed in brain, heart, lung and spleen. Low level in liver and testis