LMPD Database

LMP012991

Gene Information

Entrez Gene ID	266610
Gene Name	Fas (TNFRSF6)-associated via death domain
Gene Symbol	Fadd
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0031265	IDA:RGD	C	CD95 death-inducing signaling complex
GO:0044297	IDA:RGD	C	cell body
GO:0005737	IDA:RGD	C	cytoplasm
GO:0031264	IDA:RGD	C	death-inducing signaling complex
GO:0045121	IDA:RGD	C	membrane raft
GO:0043005	IDA:RGD	C	neuron projection
GO:0043234	IDA:RGD	C	protein complex
GO:0097342	ISS:UniProtKB	C	ripoptosome
GO:0005123	IPI:RGD	F	death receptor binding
GO:0002020	IPI:RGD	F	protease binding
GO:0032403	IPI:RGD	F	protein complex binding
GO:0005164	IPI:RGD	F	tumor necrosis factor receptor binding
GO:0097202	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity
GO:0006915	ISS:UniProtKB	P	apoptotic process
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0051607	IEA:Ensembl	P	defense response to virus
GO:0097192	IEA:Ensembl	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0048535	ISS:UniProtKB	P	lymph node development
GO:0097049	IEA:Ensembl	P	motor neuron apoptotic process
GO:0097527	IEA:Ensembl	P	necroptotic signaling pathway
GO:0070236	ISS:UniProtKB	P	negative regulation of activation-induced cell death of T cells
GO:0060546	IEA:Ensembl	P	negative regulation of necroptotic process
GO:0042104	ISS:UniProtKB	P	positive regulation of activated T cell proliferation
GO:0002821	ISS:UniProtKB	P	positive regulation of adaptive immune response
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:2000454	ISS:UniProtKB	P	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:1902043	IEA:Ensembl	P	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043123	IEA:Ensembl	P	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032729	ISS:UniProtKB	P	positive regulation of interferon-gamma production
GO:0032757	IEA:Ensembl	P	positive regulation of interleukin-8 production
GO:0045651	IEA:Ensembl	P	positive regulation of macrophage differentiation
GO:0045862	IEA:Ensembl	P	positive regulation of proteolysis
GO:0001916	ISS:UniProtKB	P	positive regulation of T cell mediated cytotoxicity
GO:0045944	IEA:Ensembl	P	positive regulation of transcription from RNA polymerase II promoter
GO:0032760	IEA:Ensembl	P	positive regulation of tumor necrosis factor production
GO:0060340	IEA:Ensembl	P	positive regulation of type I interferon-mediated signaling pathway
GO:0051291	IPI:RGD	P	protein heterooligomerization
GO:0048536	ISS:UniProtKB	P	spleen development
GO:0033077	ISS:UniProtKB	P	T cell differentiation in thymus
GO:0043029	ISS:UniProtKB	P	T cell homeostasis
GO:0048538	ISS:UniProtKB	P	thymus development
GO:0036462	IEA:Ensembl	P	TRAIL-activated apoptotic signaling pathway

KEGG Pathway Links

KEGG Pathway ID	Description
ko05010	Alzheimer's disease
rno05010	Alzheimer's disease
ko04210	Apoptosis
rno04210	Apoptosis
ko05142	Chagas disease (American trypanosomiasis)
rno05142	Chagas disease (American trypanosomiasis)
rno05161	Hepatitis B
ko05168	Herpes simplex infection
rno05168	Herpes simplex infection
rno05200	Pathways in cancer
ko04622	RIG-I-like receptor signaling pathway
rno04622	RIG-I-like receptor signaling pathway
ko04668	TNF signaling pathway
rno04668	TNF signaling pathway
ko04620	Toll-like receptor signaling pathway
rno04620	Toll-like receptor signaling pathway
ko05152	Tuberculosis
rno05152	Tuberculosis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953551	Activated TLR4 signalling
5953314	Apoptosis
5953376	Caspase-8 activation by cleavage
5953312	Death Receptor Signalling
5953375	Dimerization of procaspase-8
5953313	Extrinsic Pathway for Apoptosis
5953311	FasL/ CD95L signaling
5953410	Immune System
5953409	Innate Immune System
5953559	MyD88-independent cascade
5953799	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
5954619	Regulation by c-FLIP
5953789	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
5953560	Toll Like Receptor 3 (TLR3) Cascade
5953552	Toll Like Receptor 4 (TLR4) Cascade
5953553	Toll-Like Receptors Cascades
5953450	TRAIL signaling
5954589	TRIF-mediated programmed cell death
5953558	TRIF-mediated TLR3/TLR4 signaling