LMPD Database

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LMP012990

UniProt Annotations

Entry Information
Gene Namefree fatty acid receptor 1
Protein EntryFFAR1_RAT
UniProt IDQ8K3T4
SpeciesRat
Comments
Comment typeDescription
FunctionG-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)- mediated pathway. {ECO:0000250|UniProtKB:O14842, ECO:0000250|UniProtKB:Q76JU9}.
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed abundantly in pancreatic beta cells