LMPD Database

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LMP012987

UniProt Annotations

Entry Information
Gene NameFK506 binding protein 4
Protein EntryFKBP4_RAT
UniProt IDQ9QVC8
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPeptidylproline (omega=180) = peptidylproline (omega=0).
DomainThe chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400
DomainThe C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
DomainThe PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA)
DomainThe TPR repeats mediate mitochondrial localization
Enzyme RegulationInhibited by FK506
FunctionImmunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. May have a protective role against oxidative stress in mitochondria (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. The PPIase activity controls neuronal growth cones via regulation of TRPC1 channel opening. {ECO:0000250, ECO:0000269|PubMed:17435176, ECO:0000269|PubMed:20133804}.
PtmPhosphorylation by CK2 results in loss of HSP90 binding activity.
SimilarityContains 2 PPIase FKBP-type domains
SimilarityContains 3 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.
Subcellular LocationCytoplasm, cytosol . Mitochondrion {ECO:0000250}. Nucleus . Cytoplasm, cytoskeleton . Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (By similarity). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons
SubunitHomodimer (By similarity). Associates (via TPR domains) with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha- hydroxylase (PHYH) (By similarity). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex (By similarity). Associates with tubulin (By similarity). Interacts with MAPT/TAU; the interaction is enhanced for phosphorylated MAPT/TAU. Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent (By similarity). Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction (By similarity)
Tissue SpecificityWidely detected in the brain (at protein level)
Web ResourceName=Protein Spotlight; Note=A mind astray - Issue 118 of June 2010; URL="http://web.expasy.org/spotlight/back_issues/118";