LMPD Database

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LMP012956

UniProt Annotations

Entry Information
Gene Nameprostaglandin reductase 1
Protein EntryPTGR1_RAT
UniProt IDP97584
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13- dienoate + NAD(P)H.
Catalytic ActivityA n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
FunctionFunctions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12- oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity)
InductionUp-regulated by 1,2-dithiole-3-thione (D3T)
SimilarityBelongs to the NADP-dependent oxidoreductase L4BD family
Subcellular LocationCytoplasm .
SubunitMonomer or homodimer