LMPD Database

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LMP012954

UniProt Annotations

Entry Information
Gene Namesurfactant protein B
Protein EntryPSPB_RAT
UniProt IDP22355
SpeciesRat
Comments
Comment typeDescription
FunctionPulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
MiscellaneousPulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
SimilarityContains 1 saposin A-type domain
SimilarityContains 3 saposin B-type domains
Subcellular LocationSecreted, extracellular space, surface film.
SubunitHomodimer; disulfide-linked.