LMPD Database

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LMP012899

UniProt Annotations

Entry Information
Gene Namephospholipid scramblase 1
Protein EntryPLS1_RAT
UniProt IDP58195
SpeciesRat
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ;
DomainThe N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity
FunctionMay mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
FunctionMay play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation (By similarity)
PtmPhosphorylated on tyrosine residues
SimilarityBelongs to the phospholipid scramblase family
Subcellular LocationMembrane ; Single-pass type II membrane protein. Membrane; Lipid-anchor ; Cytoplasmic side. Nucleus .