LMPD Database

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LMP012882

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-4-phosphatase, type II
Protein EntryINP4B_RAT
UniProt IDQ9QWG5
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q9QWG5-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9QWG5-2; Sequence=VSP_015249; Note=Inactive.;
Biophysicochemical PropertiesKinetic parameters: KM=39 uM for inositol 3,4-bisphosphate ; KM=34 uM for inositol 1,3,4-trisphosphate ; Vmax=26 umol/min/mg enzyme with inositol 3,4-bisphosphate as substrate ; Vmax=22 umol/min/mg enzyme with inositol 1,3,4-trisphosphate as substrate ; pH dependence: Optimum pH is 7-8. ;
Catalytic Activity1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Enzyme RegulationStrongly inhibited by inositol hexakisphosphate
FunctionCatalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.
PathwaySignal transduction; phosphatidylinositol signaling pathway.
SimilarityBelongs to the inositol 3,4-bisphosphate 4-phosphatase family
SimilarityContains 1 C2 domain