LMPD Database

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LMP012833

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol binding clathrin assembly protein
Protein EntryPICAL_RAT
UniProt IDO55012
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 ; Synonyms=Long ; IsoId=O55012-1; Sequence=Displayed; Name=2 ; Synonyms=Short ; IsoId=O55012-2; Sequence=VSP_050687;
FunctionAssembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction (By similarity)
InteractionSelf; NbExp=3; IntAct=EBI-915601, EBI-915601; P63027:VAMP2 (xeno); NbExp=2; IntAct=EBI-915601, EBI-520113; Q15836:VAMP3 (xeno); NbExp=2; IntAct=EBI-915601, EBI-722343; O70404:Vamp8 (xeno); NbExp=4; IntAct=EBI-915601, EBI-1812572;
SimilarityBelongs to the PICALM/SNAP91 family
SimilarityContains 1 ENTH (epsin N-terminal homology) domain
Subcellular LocationMembrane, clathrin-coated pit . Golgi apparatus . Cytoplasmic vesicle, clathrin- coated vesicle {ECO:0000250}. Nucleus . Note=Colocalized with clathrin in the Golgi area. Interaction with FAM64A may target PICALM to the nucleus in some cells
SubunitBinds clathrin and phosphatidylinositol 4,5-bisphosphate. Interacts with FAM64A; this interaction may change the subcellular location into the nucleus (By similarity)
Tissue SpecificityIsoform 2 was found in most tissues examined. Isoform 1 has an overlapping expression pattern but is absent from lung, heart and pancreas. Both isoforms are widely expressed in the brain, higher levels are seen in hippocampus, dentate gyrus, medial habenula nucleus and cerebellar granule cells