LMPD Database

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LMP012723

UniProt Annotations

Entry Information
Gene Namesyntaxin 12
Protein EntrySTX12_RAT
UniProt IDG3V7P1
SpeciesRat
Comments
Comment typeDescription
FunctionSNARE that acts to regulate protein transport between endosomes and the trans-Golgi network (By similarity). The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro)
InteractionQ63666:Vamp1; NbExp=3; IntAct=EBI-915654, EBI-2029956;
Sequence CautionSequence=AAC18967.1; Type=Frameshift; Positions=2; Evidence= ;
SimilarityBelongs to the syntaxin family
SimilarityContains 1 t-SNARE coiled-coil homology domain
Subcellular LocationEndosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system ; Single-pass type IV membrane protein ; Cytoplasmic side .
SubunitAssociates with the BLOC-1 complex. Interacts with BLOC1S6 (By similarity). Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. {ECO:0000250, ECO:0000269|PubMed:17159904, ECO:0000269|PubMed:9507000}.
Tissue SpecificityUbiquitous. Highly expressed in brain