LMPD Database

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LMP012720

UniProt Annotations

Entry Information
Gene NameDnaJ (Hsp40) homolog, subfamily A, member 1
Protein EntryDNJA1_RAT
UniProt IDP63036
SpeciesRat
Comments
Comment typeDescription
FunctionFunctions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity). Co- chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573). {ECO:0000250, ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:9605323}.
SimilarityContains 1 CR-type zinc finger
SimilarityContains 1 J domain
Subcellular LocationMembrane ; Lipid-anchor {ECO:0000250}. Cytoplasm . Microsome . Mitochondrion . Nucleus . Cytoplasm, perinuclear region . Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria.
SubunitIdentified in a complex with HSPA1B and BAX
Tissue SpecificityDetected in liver (at protein level)