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LMPD Database

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LMP012699

UniProt Annotations

Entry Information

Gene Name	plasmolipin
Protein Entry	PLLP_RAT
UniProt ID	P47987
Species	Rat

Comments

Comment type	Description
Developmental Stage	In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.
Function	Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective.
Sequence Caution	Sequence=AAA62133.1; Type=Erroneous initiation; Evidence= ;
Similarity	Belongs to the MAL family
Similarity	Contains 1 MARVEL domain. {ECO:0000255\|PROSITE- ProRule:PRU00581}.
Subcellular Location	Membrane ; Multi-pass membrane protein .
Subunit	Hexamer arranged as a trimer of two plasmolipin subunits.
Tissue Specificity	Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tublar epithelia.