LMPD Database

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LMP012646

Gene Information

Entrez Gene ID54226
Gene Nameamyloid beta (A4) precursor protein
Gene SymbolApp
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 IEA:EnsemblCapical part of cell
GO:0030424 ISS:UniProtKBCaxon
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0009986 IDA:AgBaseCcell surface
GO:0035253 IEA:EnsemblCciliary rootlet
GO:0005905 IEA:UniProtKB-KWCcoated pit
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0043198 IEA:EnsemblCdendritic shaft
GO:0043197 IEA:EnsemblCdendritic spine
GO:0030134 IEA:EnsemblCER to Golgi transport vesicle
GO:0005615 IEA:EnsemblCextracellular space
GO:0070062 IEA:EnsemblCextracellular vesicular exosome
GO:0005794 ISS:UniProtKBCGolgi apparatus
GO:0016021 ISS:UniProtKBCintegral component of membrane
GO:0045121 IEA:EnsemblCmembrane raft
GO:0031594 IEA:EnsemblCneuromuscular junction
GO:0043005 IDA:RGDCneuron projection
GO:0005641 IEA:EnsemblCnuclear envelope lumen
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005886 IEA:EnsemblCplasma membrane
GO:0043235 IEA:EnsemblCreceptor complex
GO:0051233 IEA:EnsemblCspindle midzone
GO:0003677 ISS:UniProtKBFDNA binding
GO:0070851 IPI:RGDFgrowth factor receptor binding
GO:0008201 IEA:UniProtKB-KWFheparin binding
GO:0016504 IDA:RGDFpeptidase activator activity
GO:0004867 IEA:UniProtKB-KWFserine-type endopeptidase inhibitor activity
GO:0046914 IEA:InterProFtransition metal ion binding
GO:0008344 ISS:UniProtKBPadult locomotory behavior
GO:0008088 ISS:UniProtKBPaxon cargo transport
GO:0016199 ISS:UniProtKBPaxon midline choice point recognition
GO:0007409 ISS:UniProtKBPaxonogenesis
GO:0007155 IEA:UniProtKB-KWPcell adhesion
GO:0006878 ISS:UniProtKBPcellular copper ion homeostasis
GO:0008203 IEA:EnsemblPcholesterol metabolic process
GO:0048669 ISS:UniProtKBPcollateral sprouting in absence of injury
GO:0016358 ISS:UniProtKBPdendrite development
GO:0006897 ISS:UniProtKBPendocytosis
GO:0030198 ISS:UniProtKBPextracellular matrix organization
GO:0030900 IEA:EnsemblPforebrain development
GO:0035235 ISS:UniProtKBPionotropic glutamate receptor signaling pathway
GO:0007626 ISS:UniProtKBPlocomotory behavior
GO:0007617 ISS:UniProtKBPmating behavior
GO:0006378 ISS:UniProtKBPmRNA polyadenylation
GO:0045665 IEA:EnsemblPnegative regulation of neuron differentiation
GO:0050885 IEA:EnsemblPneuromuscular process controlling balance
GO:0051402 IEA:EnsemblPneuron apoptotic process
GO:0031175 ISS:UniProtKBPneuron projection development
GO:0016322 ISS:UniProtKBPneuron remodeling
GO:0007219 IEA:UniProtKB-KWPNotch signaling pathway
GO:0010971 IEA:EnsemblPpositive regulation of G2/M transition of mitotic cell cycle
GO:0045931 ISS:UniProtKBPpositive regulation of mitotic cell cycle
GO:0010952 IDA:GOCPpositive regulation of peptidase activity
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0006468 ISS:UniProtKBPprotein phosphorylation
GO:0007176 ISS:UniProtKBPregulation of epidermal growth factor-activated receptor activity
GO:0040014 ISS:UniProtKBPregulation of multicellular organism growth
GO:0043393 IEA:EnsemblPregulation of protein binding
GO:0050803 ISS:UniProtKBPregulation of synapse structure and activity
GO:0006417 ISS:UniProtKBPregulation of translation
GO:0006979 IEA:EnsemblPresponse to oxidative stress
GO:0051563 IEA:EnsemblPsmooth endoplasmic reticulum calcium ion homeostasis
GO:0001967 IEA:EnsemblPsuckling behavior
GO:0051124 IEA:EnsemblPsynaptic growth at neuromuscular junction
GO:0008542 ISS:UniProtKBPvisual learning
KEGG Pathway Links
KEGG Pathway IDDescription
ko05010Alzheimer's disease
rno05010Alzheimer's disease
rno04726Serotonergic synapse
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953551Activated TLR4 signalling
5954355Advanced glycosylation endproduct receptor signaling
5954397Amyloids
5954122Class A/1 (Rhodopsin-like receptors)
5953792Cytosolic sensors of pathogen-associated DNA
5953794DEx/H-box helicases activate type I IFN and inflammatory cytokines production
5953253Disease
5954200Formyl peptide receptors bind formyl peptides and many other ligands
5954152G alpha (i) signalling events
5953653G alpha (q) signalling events
5953537Gastrin-CREB signalling pathway via PKC and MAPK
5953642GPCR downstream signaling
5953758GPCR ligand binding
5953645Hemostasis
5953410Immune System
5953409Innate Immune System
5953565MyD88 cascade initiated on plasma membrane
5953562MyD88 dependent cascade initiated on endosome
5953559MyD88-independent cascade
5953550MyD88:Mal cascade initiated on plasma membrane
5954121Peptide ligand-binding receptors
5953644Platelet activation, signaling and aggregation
5954102Platelet degranulation
5953646Response to elevated platelet cytosolic Ca2+
5953789RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
5953790RIP-mediated NFkB activation via ZBP1
5953391Signaling by GPCR
5953381Signal Transduction
5953787TAK1 activates NFkB by phosphorylation and activation of IKKs complex
5953566Toll Like Receptor 10 (TLR10) Cascade
5953555Toll Like Receptor 2 (TLR2) Cascade
5953560Toll Like Receptor 3 (TLR3) Cascade
5953552Toll Like Receptor 4 (TLR4) Cascade
5953567Toll Like Receptor 5 (TLR5) Cascade
5953564Toll Like Receptor 7/8 (TLR7/8) Cascade
5953563Toll Like Receptor 9 (TLR9) Cascade
5953553Toll-Like Receptors Cascades
5953554Toll Like Receptor TLR1:TLR2 Cascade
5953556Toll Like Receptor TLR6:TLR2 Cascade
5953561TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
5953788TRAF6 mediated NF-kB activation
5953558TRIF-mediated TLR3/TLR4 signaling
5953791ZBP1(DAI) mediated induction of type I IFNs