LMPD Database

LMP012626

Gene Information

Entrez Gene ID	29702
Gene Name	eukaryotic translation initiation factor 2 alpha kinase 3
Gene Symbol	Eif2ak3
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005623	IDA:RGD	C	cell
GO:0005789	IEA:Ensembl	C	endoplasmic reticulum membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004694	ISS:UniProtKB	F	eukaryotic translation initiation factor 2alpha kinase activity
GO:0004674	IDA:RGD	F	protein serine/threonine kinase activity
GO:0006919	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282	IEA:Ensembl	P	bone mineralization
GO:0019722	IEA:Ensembl	P	calcium-mediated signaling
GO:0002063	IEA:Ensembl	P	chondrocyte development
GO:0031018	ISS:UniProtKB	P	endocrine pancreas development
GO:0007029	IEA:Ensembl	P	endoplasmic reticulum organization
GO:0030968	ISS:UniProtKB	P	endoplasmic reticulum unfolded protein response
GO:0006983	ISS:UniProtKB	P	ER overload response
GO:0045444	IEA:Ensembl	P	fat cell differentiation
GO:0048009	IEA:Ensembl	P	insulin-like growth factor receptor signaling pathway
GO:0070059	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007595	IEA:Ensembl	P	lactation
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0010629	IEA:Ensembl	P	negative regulation of gene expression
GO:0031642	IEA:Ensembl	P	negative regulation of myelination
GO:0032057	TAS:RGD	P	negative regulation of translational initiation in response to stress
GO:0032055	IDA:RGD	P	negative regulation of translation in response to stress
GO:0001503	ISS:UniProtKB	P	ossification
GO:0032092	IEA:Ensembl	P	positive regulation of protein binding
GO:0009967	IEA:Ensembl	P	positive regulation of signal transduction
GO:0046777	ISS:UniProtKB	P	protein autophosphorylation
GO:0051260	ISS:UniProtKB	P	protein homooligomerization
GO:0006468	IDA:RGD	P	protein phosphorylation
GO:0019217	IEA:Ensembl	P	regulation of fatty acid metabolic process
GO:0032933	IEA:Ensembl	P	SREBP signaling pathway
GO:0006412	IEA:Ensembl	P	translation

KEGG Pathway Links

KEGG Pathway ID	Description
ko05010	Alzheimer's disease
rno05010	Alzheimer's disease
ko05169	Epstein-Barr virus infection
rno05169	Epstein-Barr virus infection
ko05160	Hepatitis C
rno05160	Hepatitis C
ko05168	Herpes simplex infection
rno05168	Herpes simplex infection
ko05164	Influenza A
rno05164	Influenza A
ko05162	Measles
rno05162	Measles
ko04932	Non-alcoholic fatty liver disease (NAFLD)
rno04932	Non-alcoholic fatty liver disease (NAFLD)
ko04141	Protein processing in endoplasmic reticulum
rno04141	Protein processing in endoplasmic reticulum

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953345	Metabolism of proteins
5954164	PERK regulates gene expression
5954163	Unfolded Protein Response (UPR)