LMPD Database

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LMP012625

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IIA (platelets, synovial fluid)
Protein EntryPA2GA_RAT
UniProt IDP14423
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 1 Ca(2+) ion per subunit. ;
FunctionThought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
MiscellaneousGroup II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene.
SimilarityBelongs to the phospholipase A2 family
Subcellular LocationMembrane; Peripheral membrane protein.