LMPD Database

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LMP012624

UniProt Annotations

Entry Information
Gene Namemultiple inositol-polyphosphate phosphatase 1
Protein EntryMINP1_RAT
UniProt IDO35217
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=6.9 uM for Ins(1,3,4,5)P(4) ; Vmax=302 pmol/min/ug enzyme ;
Catalytic Activity2,3-bisphospho-D-glycerate + H(2)O = 2- phospho-D-glycerate + phosphate
Catalytic ActivityMyo-inositol hexakisphosphate + H(2)O = myo- inositol pentakisphosphate (mixed isomers) + phosphate
FunctionActs as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification)
SimilarityBelongs to the histidine acid phosphatase family. MINPP1 subfamily
Subcellular LocationEndoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:8384201}.
Tissue SpecificityWidely expressed with highest levels in kidney and liver. Expressed in chondrocytes with an elevated expression in hypertrophic chondrocytes. {ECO:0000269|PubMed:9359836, ECO:0000269|PubMed:9923613}.