LMPD Database

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LMP012579

UniProt Annotations

Entry Information
Gene Namesigma non-opioid intracellular receptor 1
Protein EntrySGMR1_RAT
UniProt IDQ9R0C9
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9R0C9-1; Sequence=Displayed; Name=2; IsoId=Q9R0C9-2; Sequence=VSP_021988, VSP_021989;
FunctionFunctions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. {ECO:0000269|PubMed:11861817, ECO:0000269|PubMed:11988171, ECO:0000269|PubMed:15170821, ECO:0000269|PubMed:15466698, ECO:0000269|PubMed:16522641, ECO:0000269|PubMed:9489711}.
InteractionP06761:Hspa5; NbExp=3; IntAct=EBI-1557826, EBI-916036; P63141:Kcna2 (xeno); NbExp=3; IntAct=EBI-1557826, EBI-644033;
MiscellaneousDepletion by RNAi alters oligodendrocyte differentiation and enhances opioid analgesia.
SimilarityBelongs to the ERG2 family
Subcellular LocationNucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding.
SubunitForms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4
Tissue SpecificityExpressed in ependymocytes and neurons throughout the CNS from the olfactory bulb to the spinal cord. Expressed by progenitor, mature and satellite oligodendrocytes and by Schwann cells (at protein level). Expressed in liver, intestine, kidney, brain, lung and heart. Expressed by retinal cells. {ECO:0000269|PubMed:10771347, ECO:0000269|PubMed:11687279, ECO:0000269|PubMed:12535781, ECO:0000269|PubMed:15064136, ECO:0000269|PubMed:9489711}.