LMPD Database

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LMP012540

UniProt Annotations

Entry Information
Gene Nameprostaglandin F receptor
Protein EntryPF2R_RAT
UniProt IDP43118
SpeciesRat
Comments
Comment typeDescription
FunctionReceptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityHighest expression in pregnant ovary. Also found in a low extent in the kidney. In the brain, expressed in astrocytes and oligodendrocytes, and meningeal fibroblasts, but not in migroglia cells.