LMPD Database

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LMP012498

UniProt Annotations

Entry Information
Gene Namefarnesyltransferase, CAAX box, alpha
Protein EntryFNTA_RAT
UniProt IDQ04631
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Enzyme RegulationActivated by the AGRIN-induced phosphorylation which is mediated by MUSK
FunctionEssential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:22963166}.
InteractionQ02293:Fntb; NbExp=14; IntAct=EBI-602447, EBI-602454; P01116-2:KRAS (xeno); NbExp=2; IntAct=EBI-602447, EBI-367427; P53610:Pggt1b; NbExp=5; IntAct=EBI-602447, EBI-602610;
PtmPhosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity)
SimilarityBelongs to the protein prenyltransferase subunit alpha family
SimilarityContains 5 PFTA repeats. {ECO:0000255|PROSITE- ProRule:PRU00488}.
SubunitInteracts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase). {ECO:0000250, ECO:0000269|PubMed:10377218, ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12657282, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15170324, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9065406, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}.