LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012424

UniProt Annotations

Entry Information
Gene Nameprotein kinase, cAMP dependent regulatory, type II beta
Protein EntryKAP3_RAT
UniProt IDP12369
SpeciesRat
Comments
Comment typeDescription
FunctionRegulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
InteractionQ5S007:LRRK2 (xeno); NbExp=3; IntAct=EBI-6096160, EBI-5323863; P17612:PRKACA (xeno); NbExp=2; IntAct=EBI-6096160, EBI-476586;
PtmPhosphorylated by the activated catalytic chain
SimilarityBelongs to the cAMP-dependent kinase regulatory chain family
SimilarityContains 2 cyclic nucleotide-binding domains
Subcellular LocationCytoplasm . Cell membrane . Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane
SubunitThe inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2 (By similarity)
Tissue SpecificityFour types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Brain. Present in a few pyramidal neurons and mostly in mossy fibers. Colocalizes with PJA2 in dentate granule cells and at postsynaptic sites of primary hippocampal neurons