LMPD Database

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LMP012382

UniProt Annotations

Entry Information
Gene Nameserine palmitoyltransferase, long chain base subunit 3
Protein EntrySPTC3_HUMAN
UniProt IDQ9NUV7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NUV7-1; Sequence=Displayed; Name=2; IsoId=Q9NUV7-2; Sequence=VSP_028167, VSP_028168; Note=Variant in position: 149:P->A (in dbSNP:rs934335).;
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2). {ECO:0000269|PubMed:17023427, ECO:0000269|PubMed:19416851}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= ;
FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference
PathwayLipid metabolism; sphingolipid metabolism.
Sequence CautionSequence=AAH05205.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence= ;
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein
SubunitHeterodimer with SPTLC1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1/SPTLC1, LCB2 (SPTLC2 or SPTLC3) and ssPT (SPTSSA and SPTSSB)
Tissue SpecificityExpressed in most tissues, except peripheral blood cells and bone marrow, with highest levels in heart, kidney, liver, uterus and skin