LMPD Database

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LMP012372

UniProt Annotations

Entry Information
Gene Namephospholipase D family, member 6
Protein Entry
UniProt IDQ8N2A8
SpeciesHuman
Comments
Comment typeDescription
DomainIn contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site
Enzyme RegulationSsDNA hydrolase activity does not depend upon, but it stimulated by, the presence of Ca(2+) and Mn(2+)
FunctionRegulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol. {ECO:0000250, ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397848}.
SimilarityBelongs to the phospholipase D family. MitoPLD/Zucchini subfamily
SimilarityContains 1 C3H1-type zinc finger
SimilarityContains 1 PLD phosphodiesterase domain
Subcellular LocationMitochondrion outer membrane ; Single-pass membrane protein
SubunitHomodimer
Tissue SpecificityWidely expressed. Expression is not limited to testis and ovary. {ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847}.