LMPD Database

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LMP012349

Record overview

LMPD IDLMP012349
Gene ID9374
SpeciesHomo sapiens (Human)
Gene Namepalmitoyl-protein thioesterase 2
Gene SymbolPPT2
SynonymsG14; PPT-2; C6orf8;
Chromosome6
Map Location6p21.3
EC Number3.1.2.-
SummaryThis gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]
OrthologsView orthologs and multiple alignments for PPT2

Proteins

lysosomal thioesterase PPT2 isoform a precursor
Refseq ID:NP_005146
Protein GI:323362946
UniProt ID:Q9UMR5
mRNA ID:NM_005155
Length:302
RefSeq Status:
MLGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHRASYKPVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAK
APQGVHLICYSQGGLVCRALLSVMDDHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALING
ERDHPNATVWRKNFLRVGHLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPW
LS
 
lysosomal thioesterase PPT2 isoform a precursor
Refseq ID:NP_001191032
Protein GI:323362948
UniProt ID:Q9UMR5
mRNA ID:NM_001204103
Length:302
RefSeq Status:
Protein sequence is identical to GI:323362946 (mRNA isoform)
 
lysosomal thioesterase PPT2 isoform b precursor
Refseq ID:NP_619731
Protein GI:323362944
UniProt ID:Q9UMR5
mRNA ID:NM_138717
Length:308
RefSeq Status:
MKSCGSMLGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHRASYKPVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAV
VPIMAKAPQGVHLICYSQGGLVCRALLSVMDDHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSF
LALINGERDHPNATVWRKNFLRVGHLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYE
TCIEPWLS
 
sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2946
peptide sequence: 
MLGLCGQRLPAAWVLLLLPFLPLLLLA
mat_peptide: 28..302
product: Lysosomal thioesterase PPT2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9UMR5.4)
calculated_mol_wt: 31298
peptide sequence: 
APAPHRASYKPVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRALLSVMDDH
NVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRVGHLVLIGGPD
DGVITPWQSSFFGFYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPWLS
sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2946
peptide sequence: 
MLGLCGQRLPAAWVLLLLPFLPLLLLA
mat_peptide: 28..302
product: Lysosomal thioesterase PPT2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9UMR5.4)
calculated_mol_wt: 31298
peptide sequence: 
APAPHRASYKPVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRALLSVMDDH
NVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRVGHLVLIGGPD
DGVITPWQSSFFGFYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPWLS
sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3540
peptide sequence: 
MKSCGSMLGLCGQRLPAAWVLLLLPFLPLLLLA
mat_peptide: 34..308
product: lysosomal thioesterase PPT2 isoform b
calculated_mol_wt: 31298
peptide sequence: 
APAPHRASYKPVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRALLSVMDDH
NVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRVGHLVLIGGPD
DGVITPWQSSFFGFYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPWLS