LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012345

Gene Information

Entrez Gene ID4041
Gene Namelow density lipoprotein receptor-related protein 5
Gene SymbolLRP5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005783 IEA:UniProtKB-KWCendoplasmic reticulum
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0043235 IDA:BHF-UCLCreceptor complex
GO:0015026 IBA:RefGenomeFcoreceptor activity
GO:0042813 IBA:RefGenomeFWnt-activated receptor activity
GO:0017147 IBA:RefGenomeFWnt-protein binding
GO:0060612 IMP:BHF-UCLPadipose tissue development
GO:0060033 IEA:EnsemblPanatomical structure regression
GO:0009952 IBA:RefGenomePanterior/posterior pattern specification
GO:1902262 IEA:EnsemblPapoptotic process involved in patterning of blood vessels
GO:0048539 IMP:BHF-UCLPbone marrow development
GO:0060349 IMP:BHF-UCLPbone morphogenesis
GO:0046849 IBA:RefGenomePbone remodeling
GO:0060444 IBA:RefGenomePbranching involved in mammary gland duct morphogenesis
GO:0060070 IDA:BHF-UCLPcanonical Wnt signaling pathway
GO:0060764 IEA:EnsemblPcell-cell signaling involved in mammary gland development
GO:0042074 IEA:EnsemblPcell migration involved in gastrulation
GO:0042632 IMP:BHF-UCLPcholesterol homeostasis
GO:0008203 IEA:EnsemblPcholesterol metabolic process
GO:0048596 IBA:RefGenomePembryonic camera-type eye morphogenesis
GO:0042733 IEA:EnsemblPembryonic digit morphogenesis
GO:0030326 IBA:RefGenomePembryonic limb morphogenesis
GO:0060059 IBA:RefGenomePembryonic retina morphogenesis in camera-type eye
GO:0006897 IEA:UniProtKB-KWPendocytosis
GO:0035426 IEA:EnsemblPextracellular matrix-cell signaling
GO:0001702 IBA:RefGenomePgastrulation with mouth forming second
GO:0006007 IMP:BHF-UCLPglucose catabolic process
GO:0045668 IMP:BHF-UCLPnegative regulation of osteoblast differentiation
GO:0071901 IMP:BHF-UCLPnegative regulation of protein serine/threonine kinase activity
GO:0002076 IBA:RefGenomePosteoblast development
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0045600 IMP:BHF-UCLPpositive regulation of fat cell differentiation
GO:0002053 IMP:BHF-UCLPpositive regulation of mesenchymal cell proliferation
GO:0045840 IDA:BHF-UCLPpositive regulation of mitosis
GO:0033690 IEA:EnsemblPpositive regulation of osteoblast proliferation
GO:0051091 IEA:EnsemblPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0042981 IEA:EnsemblPregulation of apoptotic process
GO:0008217 IMP:BHF-UCLPregulation of blood pressure
GO:0046850 IEA:EnsemblPregulation of bone remodeling
GO:0060828 IMP:BHF-UCLPregulation of canonical Wnt signaling pathway
GO:0061178 IBA:RefGenomePregulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043434 IEA:EnsemblPresponse to peptide hormone
GO:0061304 IMP:BHF-UCLPretinal blood vessel morphogenesis
GO:0060042 IMP:BHF-UCLPretina morphogenesis in camera-type eye
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0016055 IDA:BHF-UCLPWnt signaling pathway
GO:0044332 IDA:BHF-UCLPWnt signaling pathway involved in dorsal/ventral axis specification
KEGG Pathway Links
KEGG Pathway IDDescription
hsa04310Wnt signaling pathway
ko04310Wnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_200610disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_228096misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_200643negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_200716regulation of FZD by ubiquitination
REACT_228188RNF mutants show enhanced WNT signaling and proliferation
REACT_11045Signaling by Wnt
REACT_228331Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_200777TCF dependent signaling in response to WNT
REACT_228279XAV939 inhibits tankyrase, stabilizing AXIN