LMPD Database

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LMP012138

UniProt Annotations

Entry Information
Gene Namespinster homolog 2 (Drosophila)
Protein EntrySPNS2_DANRE
UniProt IDA9JRX4
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageInduced at the marginal cells of the blastoderm at dome stage. During gastrulation stages, it is predominantly expressed in the extraembryonic yolk syncytial layer (YSL) with a dorsal-to-ventral gradient. Expression in the YSL is strongly detected just below the developing myocardial precursors and maintained throughout segmentation period. This expression continues through early somitogenesis. However, as somitogenesis proceeds, expression domains become evident in the somitic mesoderm and in the endoderm adjacent to the yolk extension. By 24 hpf, it is strongly expressed in a distinct compartment of the somites, in the endoderm, and in the heart. {ECO:0000269|PubMed:19062281, ECO:0000269|PubMed:19074308}.
Disruption Phenotypedisrupted formation of the primitive heart tube. {ECO:0000269|PubMed:19062281}.
FunctionSphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration. {ECO:0000269|PubMed:19062281, ECO:0000269|PubMed:19074308}.
SimilarityBelongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.