LMPD Database

LMP011555

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 26, subfamily b, polypeptide 1
Protein EntryQ6EIG3_DANRE
UniProt IDQ6EIG3
SpeciesZebrafish
Comments
Comment typeDescription
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Developmental StageExpressed zygotically. Weak expression at 75% epiboly. At the 2-somite stage, expressed in the presumptive rhombomere 4 (r4) region partially overlapping with the r3 region. At the 10-somite stage, expressed in the r4, r3 and r2 regions. At the 14-somite stage, expression extends to the r5 and r6 regions and is observed in the diencephalon. At 24-48 hours post- fertilization (hpf), additionally expressed in the eye, midbrain- hindbrain boundary, cerebellum, pectoral fin and the pharyngeal arch primordia.
FunctionInvolved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .