LMPD Database

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LMP010762

UniProt Annotations

Entry Information
Gene NamePeroxisome biogenesis protein 12
Protein EntryPEX12_ARATH
UniProt IDQ9M841
SpeciesArabidopsis
Comments
Comment typeDescription
Disruption PhenotypeEmbryo lethality at the heart stage. {ECO:0000269|PubMed:16113209}.
FunctionRequired for peroxisome biogenesis and for PTS1- and PTS2-dependent protein import into peroxisomes. Essential for the peroxisomal targeting of PEX7. Required for the export/release of receptors on the peroxisome membrane. Acts as an E3 ubiquitin- protein ligase involved in monoubiquitination of PEX5. {ECO:0000269|PubMed:16113209, ECO:0000269|PubMed:16813573, ECO:0000269|PubMed:17478547, ECO:0000269|PubMed:19594707, ECO:0000269|PubMed:20679226, ECO:0000269|PubMed:23336935}.
Sequence CautionSequence=AAF63777.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC42305.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BX824646; Type=Frameshift; Positions=250; Evidence={ECO:0000305};
SimilarityBelongs to the pex2/pex10/pex12 family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000305}.
Subcellular LocationPeroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.
SubunitInteracts (via C-terminus) with PEX7. Interacts with DSK2a and DSK2b. {ECO:0000269|PubMed:19594707, ECO:0000269|PubMed:23336935}.
Tissue SpecificityExpressed in young seedlings, roots, leaves, seeds and flowers. {ECO:0000269|PubMed:16113209}.