LMPD Database

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LMP010570

UniProt Annotations

Entry Information
Gene Nameserine palmitoyltransferase
Protein EntryLCB1_ARATH
UniProt IDQ94IB8
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Disruption PhenotypeDefective Embryo and pollen lethality. RNAi mutants display plant size reduction, altered leaf morphology and increases in relative amounts of saturated sphingolipid long-chain bases. {ECO:0000269|PubMed:17194770, ECO:0000269|PubMed:18218968}.
FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with LCB2 constitutes the catalytic core. Involved in the regulation of the programmed cell death (PCD) signaling pathway. Plays an important role during male gametogenesis and embryogenesis. {ECO:0000269|PubMed:17194770, ECO:0000269|PubMed:18059378, ECO:0000269|PubMed:18218968}.
MiscellaneousThe fbr11-1 mutant is incapable of initiating programmed cell death (PCD) after induction by fumonisin B1 (FB1), a specific inhibitor of ceramide synthase.
PathwayLipid metabolism; sphingolipid metabolism.
Sequence CautionSequence=CAB16844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80314.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:17194770}; Single-pass membrane protein {ECO:0000269|PubMed:17194770}.
SubunitHeterodimer with LCB2 (LCB2a or LCB2b). Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1 and LCB2 (LCB2a or LCB2b). {ECO:0000269|PubMed:17194770}.
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:17194770}.