LMPD Database

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LMP010050

UniProt Annotations

Entry Information
Gene Nameputative clathrin interactor EPSIN 2
Protein EntryEPN2_ARATH
UniProt IDQ67YI9
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q67YI9-1; Sequence=Displayed; Name=2; IsoId=Q67YI9-2; Sequence=VSP_039700, VSP_039701;
DomainThe ENTH domain is required for PtdIns(3)P affinity and EPSIN2 subcellular location.
FunctionMay have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3)P). Plays an important role in protein trafficking. {ECO:0000250, ECO:0000269|PubMed:17277094}.
Sequence CautionSequence=AAC64305.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC64306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the epsin family. {ECO:0000305}.
SimilarityContains 1 ENTH (epsin N-terminal homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00243}.
Subcellular LocationGolgi apparatus {ECO:0000269|PubMed:17277094}. Cytoplasmic vesicle, clathrin- coated vesicle {ECO:0000269|PubMed:17277094}. Note=Localizes also to a novel cellular compartment, the 'delta compartment', characterized by colocalization of EPSIN2 and DELTA-ADR.
SubunitInteracts with clathrin, VTI12, DELTA-ADR and ALPHA-ADR. {ECO:0000269|PubMed:17277094}.