LMPD Database

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LMP009714

UniProt Annotations

Entry Information
Gene Name3-ketodihydrosphinganine reductase-like protein
Protein EntryTC10B_ARATH
UniProt IDF4JZN6
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivitySphinganine + NADP(+) = 3-dehydrosphinganine + NADPH. {ECO:0000269|PubMed:21421810}.
Disruption PhenotypeNo visible phenotype under normal growth conditions, but the double mutants tsc10a and tsc10b are not viable. {ECO:0000269|PubMed:21421810}.
FunctionCatalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Required for sphingolipid biosynthesis. In plants, sphingolipids seems to play a critical role in mineral ion homeostasis, most likely through their involvement in the ion transport functionalities of membrane systems in the root. Is stereospecific for D-erythro-DHS production and does not produce L-threo-DHS. {ECO:0000269|PubMed:21421810}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305|PubMed:21421810}; Multi-pass membrane protein {ECO:0000305|PubMed:21421810}.
Tissue SpecificityExpressed in roots, leaves, stems and flowers. {ECO:0000269|PubMed:21421810}.