LMPD Database

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LMP009011

UniProt Annotations

Entry Information
Gene Namelike-AP180
Protein EntryB7Z0U7_DROME
UniProt ID
SpeciesDrosophila
Comments
Comment typeDescription
FunctionAssembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. {ECO:0000269|PubMed:9883738}.
SimilarityBelongs to the PICALM/SNAP91 family. {ECO:0000305}.
SimilarityContains 1 ENTH (epsin N-terminal homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00243}.
Subcellular LocationMembrane, clathrin-coated pit {ECO:0000269|PubMed:9883738}. Golgi apparatus {ECO:0000269|PubMed:9883738}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:9883738}. Note=Colocalized with clathrin in the Golgi area.
SubunitBinds clathrin and phosphatidylinositol 4,5-bisphosphate. {ECO:0000250}.
Tissue SpecificityIn embryos, expression is seen in central and peripheral nervous systems (brain and ventral nerve cord) and Garland cells. Coexpressed with clathrin at presynaptic boutons of neuromuscular junctions. {ECO:0000269|PubMed:9883738}.