LMPD Database

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LMP008792

UniProt Annotations

Entry Information
Gene NameCoenzyme Q biosynthesis protein 2
Protein EntryCOQ2_DROME
UniProt IDQ9VHS7
SpeciesDrosophila
Comments
Comment typeDescription
Catalytic ActivityA polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
Disruption PhenotypeFlies exhibit a G1/S block in the third larval instar with normal neuronal differentiation. {ECO:0000269|PubMed:16849596}.
FunctionCatalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity). {ECO:0000250}.
PathwayCofactor biosynthesis; ubiquinone biosynthesis.
SimilarityBelongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.