LMPD Database

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LMP008309

UniProt Annotations

Entry Information
Gene NameProtein SEL-12
Protein EntryPSN_CAEEL
UniProt IDP52166
SpeciesC. elegans
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically. Ubiquitously expressed throughout the development and in the adult. {ECO:0000269|PubMed:12668626}.
DomainThe PAL motif is required for normal active site conformation. {ECO:0000250}.
FunctionProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. {ECO:0000269|PubMed:10917532, ECO:0000269|PubMed:12413907}.
Sequence CautionSequence=AAA85511.1; Type=Frameshift; Positions=413; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase A22A family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitHomodimer. Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable). {ECO:0000305}.
Tissue SpecificityExpressed in most neurons. {ECO:0000269|PubMed:10917532}.