LMPD Database

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LMP008017

UniProt Annotations

Entry Information
Gene NameProtein DAF-36
Protein EntryDAF36_CAEEL
UniProt IDQ17938
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityCholesterol + NADP(+) = cholesta-5,7-dien-3- beta-ol + NADPH. {ECO:0000269|PubMed:21632547, ECO:0000269|PubMed:21749634}.
CofactorName=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000255|PROSITE-ProRule:PRU00628}; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255|PROSITE- ProRule:PRU00628};
FunctionCatalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone delta(7)-dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. {ECO:0000269|PubMed:16563875, ECO:0000269|PubMed:21632547, ECO:0000269|PubMed:21749634}.
PathwaySteroid hormone biosynthesis; dafachronic acid biosynthesis. {ECO:0000269|PubMed:21632547, ECO:0000269|PubMed:21749634}.
SimilarityContains 1 Rieske domain. {ECO:0000255|PROSITE- ProRule:PRU00628}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in intestine at all postembryonic stages, including dauer. Expression is reduced in daf-2 mutants. {ECO:0000269|PubMed:16563875}.