LMPD Database

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LMP007702

UniProt Annotations

Entry Information
Gene Name2-octaprenyl-6-methoxyphenol hydroxylase, FAD/NAD(P)-binding
Protein EntryUBIH_ECOLI
UniProt IDP25534
SpeciesE. coli
Comments
Comment typeDescription
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Disruption PhenotypeCells lacking this gene are photosensitive and are not able to grow with a nonfermentable source of carbon. They also fail to produce ubiquinone, and accumulate 2- octaprenylphenol and 2-octaprenyl-6-methoxyphenol. {ECO:0000269|PubMed:1339425, ECO:0000269|PubMed:4572721}.
FunctionIs likely an oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinol. {ECO:0000269|PubMed:4572721}.
PathwayCofactor biosynthesis; ubiquinone biosynthesis.
SimilarityBelongs to the UbiH/COQ6 family. {ECO:0000305}.