LMPD Database

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LMP007700

UniProt Annotations

Entry Information
Gene Name3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Protein EntryUBIX_ECOLI
UniProt IDP0AG03
SpeciesE. coli
Comments
Comment typeDescription
CofactorName=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250}; Note=Binds 1 FMN per subunit. {ECO:0000250};
Disruption PhenotypeCells lacking this gene produce very low levels of coenzyme Q(8) during logarithmic growth, grow slowly on succinate as the sole carbon source, accumulate 4-hydroxy-3- octaprenyl-benzoate, and have reduced UbiG O-methyltransferase activity. In contrast, they synthesize near normal levels of Q(8) in the stationary phase. {ECO:0000269|PubMed:17889824}.
FunctionActs in concert with UbiD to perform the decarboxylation of 4-hydroxy-3-octaprenyl-benzoate, a step in the biosynthesis of coenzyme Q. Nevertheless, it is not clear how UbiX and UbiD act together and if UbiX has itself a decarboxylase activity. UbiX may function to deliver the substrate to its UbiD partner, which performs the decarboxylation step. {ECO:0000269|PubMed:16923914, ECO:0000269|PubMed:17889824}.
InductionDuring aerobic growth, expression depends on the carbon source, with the highest expression on succinate, a median expression on glycerol, and the lowest on glucose. During anaerobic growth, glucose does not inhibit expression. {ECO:0000269|PubMed:12799002}.
PathwayCofactor biosynthesis; ubiquinone biosynthesis.
SimilarityBelongs to the polyprenyl p-hydroxybenzoate / phenylacrylic acid decarboxylases family. {ECO:0000305}.