LMPD Database

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LMP007582

UniProt Annotations

Entry Information
Gene Name4-diphosphocytidyl-2C-methyl-D-erythritol synthase
Protein EntryISPD_ECOLI
UniProt IDQ46893
SpeciesE. coli
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 8.3.;
Catalytic ActivityCTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
FunctionCatalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP).
MiscellaneousThere are no coordination bonds that occur between IspD and magnesium in any of the complexes examined to date.
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate: step 2/6.
SimilarityBelongs to the IspD family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:11427897}.