LMPD Database

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LMP007569

UniProt Annotations

Entry Information
Gene Name4-diphosphocytidyl-2-C-methylerythritol kinase
Protein EntryISPE_ECOLI
UniProt IDP62615
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D- erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl- D-erythritol.
CautionWas originally thought to be an isopentenyl monophosphate kinase. {ECO:0000305|PubMed:1427085}.
FunctionCatalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Phosphorylates isopentenyl phosphate at low rates. Also acts on isopentenol, and, much less efficiently, dimethylallyl alcohol. Dimethylallyl monophosphate does not serve as a substrate.
InteractionP17169:glmS; NbExp=1; IntAct=EBI-562202, EBI-551022;
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate: step 3/6.
Sequence CautionSequence=BAA01106.1; Type=Frameshift; Positions=50; Evidence={ECO:0000305};
SimilarityBelongs to the GHMP kinase family. IspE subfamily. {ECO:0000305}.
SubunitHomodimer. {ECO:0000250}.