LMPD Database

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LMP007565

UniProt Annotations

Entry Information
Gene Namecardiolipin synthase 2
Protein EntryCLSB_ECOLI
UniProt IDP0AA84
SpeciesE. coli
Comments
Comment typeDescription
Catalytic Activity2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol. {ECO:0000255|HAMAP- Rule:MF_01917}.
Disruption PhenotypeTriple deletion of clsA, clsB and clsC results in a complete lack of cardiolipin, regardless of growth phase or growth conditions. {ECO:0000269|PubMed:22988102}.
Enzyme RegulationActivated by phosphate. Inhibited by cardiolipin and phosphatidate. {ECO:0000269|PubMed:10634942}.
FunctionCatalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate. {ECO:0000255|HAMAP-Rule:MF_01917, ECO:0000269|PubMed:10634942, ECO:0000269|PubMed:22988102}.
MiscellaneousAll three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase (PubMed:22988102). {ECO:0000305|PubMed:22988102}.
SimilarityBelongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily. {ECO:0000255|HAMAP- Rule:MF_01917}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|HAMAP-Rule:MF_01917}.
Subcellular LocationCell membrane {ECO:0000305|PubMed:10634942}; Peripheral membrane protein {ECO:0000305|PubMed:10634942}.