LMPD Database

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LMP007560

UniProt Annotations

Entry Information
Gene Namechorismate--pyruvate lyase
Protein EntryUBIC_ECOLI
UniProt IDP26602
SpeciesE. coli
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=29 uM for chorismate {ECO:0000269|PubMed:11825618}; pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:11825618};
Catalytic ActivityChorismate = 4-hydroxybenzoate + pyruvate.
Enzyme RegulationInhibited by 4-hydroxybenzoate, vanillate, 4- hydroxybenzaldehyde and 3-carboxymethylaminomethyl-4- hydroxybenzoic acid. {ECO:0000269|PubMed:11825618, ECO:0000269|PubMed:16343413}.
FunctionRemoves the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway.
InteractionP0AFG8:aceE; NbExp=1; IntAct=EBI-559360, EBI-542683;
PathwayCofactor biosynthesis; ubiquinone biosynthesis.
Sequence CautionSequence=AAC43133.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA40681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the UbiC family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO:0000269|PubMed:11455603}.