LMPD Database

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LMP007553

UniProt Annotations

Entry Information
Gene Namephosphatidylglycerophosphatase A
Protein EntryPGPA_ECOLI
UniProt IDP18200
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. {ECO:0000269|PubMed:20485265, ECO:0000269|PubMed:21148555, ECO:0000269|PubMed:2846510, ECO:0000269|PubMed:6296050}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:21148555};
Disruption PhenotypeDisplays 7-10 fold higher levels of phosphatidylglycerophosphate (PGP) than wild-type. Simultaneous deletion of pgpA and pgpB leads to 40 times higher PGP levels compared to wild-type, while simultaneous deletion of pgpA and pgpC leads to almost 100 times higher PGP levels. Lethal when combined with the deletion of both pgpB and pgpC. {ECO:0000269|PubMed:21148555, ECO:0000269|PubMed:2846510, ECO:0000269|PubMed:6296050}.
FunctionLipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). {ECO:0000269|PubMed:20485265, ECO:0000269|PubMed:21148555, ECO:0000269|PubMed:2846510, ECO:0000269|PubMed:6296050}.
PathwayPhospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.
Sequence CautionSequence=AAA24325.1; Type=Frameshift; Positions=42; Note=In addition, due to translation of the incorrect DNA strand, an unrelated ORF was predicted.; Evidence={ECO:0000305};
Subcellular LocationCell inner membrane {ECO:0000269|PubMed:21148555}; Multi-pass membrane protein {ECO:0000269|PubMed:21148555}.