LMPD Database

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LMP007525

UniProt Annotations

Entry Information
Gene Namephosphatidate phosphatase LPP1
Protein EntryLPP1_YEAST
UniProt IDQ04396
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. {ECO:0000269|PubMed:9603941}.
Catalytic ActivityDiacylglycerol pyrophosphate + H(2)O = phosphatidate + phosphate
Catalytic ActivityDiacylglycerol pyrophosphate + H(2)O = phosphatidate + phosphate. {ECO:0000269|PubMed:9603941}.
DomainThe phosphatase sequence motif I (including Arg-143) and II (including His-189) are part of the cytoplasmic loop 2 and phosphatase sequence motif III (including His-235) is part of the cytoplasmic loop 3.
Enzyme RegulationPA phosphatase activity is magnesium ion- independent and potently inhibited by N-ethylmaleimide. Also inhibited by phenylglyoxal and propranolol
Enzyme RegulationPA phosphatase activity is magnesium ion- independent and potently inhibited by N-ethylmaleimide. Also inhibited by phenylglyoxal and propranolol. {ECO:0000269|PubMed:10685032}.
FunctionCatalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA
FunctionCatalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA. {ECO:0000269|PubMed:10685032, ECO:0000269|PubMed:9603941}.
MiscellaneousPresent with 300 molecules/cell in log phase SD medium
MiscellaneousPresent with 300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the PA-phosphatase related phosphoesterase family
SimilarityBelongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Subcellular LocationGolgi apparatus membrane ; Multi-pass membrane protein .