LMPD Database

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LMP007396

UniProt Annotations

Entry Information
Gene Nameprotein farnesyltransferase
Protein EntryFNTB_YEAST
UniProt IDP22007
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityFarnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 zinc ion per subunit. ;
FunctionCatalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins such as a-factor and RAS. The beta subunit is responsible for peptide-binding.
InteractionP29703:RAM2; NbExp=4; IntAct=EBI-14806, EBI-14814;
MiscellaneousPresent with 3910 molecules/cell in log phase SD medium
MiscellaneousPresent with 3910 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the protein prenyltransferase subunit beta family
SimilarityBelongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
SimilarityContains 5 PFTB repeats
SimilarityContains 5 PFTB repeats. {ECO:0000305}.
SubunitHeterodimer of an alpha and a beta subunit.