LMPD Database

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LMP007363

UniProt Annotations

Entry Information
Gene NameAnt1p
Protein EntryANT1_YEAST
UniProt IDQ06497
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionAdenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation. {ECO:0000269|PubMed:11390660, ECO:0000269|PubMed:11566870, ECO:0000269|PubMed:15219179, ECO:0000269|PubMed:15316083}.
InductionInduced by oleic acid, through its ORE-like (oleate responsive element) promoter element and the PIP2-OAF1 transcription factors. {ECO:0000269|PubMed:12071844}.
MiscellaneousPresent with 2250 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the mitochondrial carrier (TC 2.A.29) family. {ECO:0000305}.
SimilarityContains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule:PRU00282}.
Subcellular LocationPeroxisome membrane {ECO:0000269|PubMed:11390660, ECO:0000269|PubMed:11566870, ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:11390660, ECO:0000269|PubMed:11566870, ECO:0000269|PubMed:14562095}.