LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007348

UniProt Annotations

Entry Information
Gene NameInn1p
Protein EntryINN1_YEAST
UniProt IDP53901
SpeciesYeast (S288c)
Comments
Comment typeDescription
DomainThe C2 domain is essential for membrane ingression during cytokinesis, but not for recruitment to the actomyosin ring
DomainThe C2 domain is essential for membrane ingression during cytokinesis, but not for recruitment to the actomyosin ring. {ECO:0000269|PubMed:18344988}.
FunctionRequired for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2. {ECO:0000269|PubMed:18344988, ECO:0000269|PubMed:19528296, ECO:0000269|PubMed:19707790}.
InteractionQ05080:HOF1; NbExp=5; IntAct=EBI-28955, EBI-5412; P80667:PEX13; NbExp=2; IntAct=EBI-28955, EBI-13206;
SimilarityBelongs to the INN1/fic1 family
SimilarityBelongs to the INN1/fic1 family. {ECO:0000305}.
SimilarityContains 1 C2 domain
SimilarityContains 1 C2 domain. {ECO:0000305}.
Subcellular LocationBud neck {ECO:0000269|PubMed:18344988, ECO:0000269|PubMed:19528296, ECO:0000269|PubMed:19707790, ECO:0000269|PubMed:20442249}. Note=Localizes at the contractile actinomyosin ring at the end of cytokinesis. Recruitment to the bud neck requires either CYK2 or CYK3.
SubunitInteracts with CYK2, CYK3 and IQG1. {ECO:0000269|PubMed:18344988, ECO:0000269|PubMed:19528296, ECO:0000269|PubMed:19707790}.