LMPD Database

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LMP007217

UniProt Annotations

Entry Information
Gene NameNte1p
Protein EntryNTE1_YEAST
UniProt IDQ04958
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Enzyme RegulationPositively regulated by SEC14. Inhibited by organophosphorus esters in the order phenyl saligenin phosphate (PSP) > phenyldipentyl phosphinate (PDPP) = diisopropyl fluorophosphate (DFP) > and paraoxon (PXN). {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:15611060}.
FunctionIntracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium. {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:15611060, ECO:0000269|PubMed:16777854}.
MiscellaneousPresent with 521 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the NTE family. {ECO:0000305}.
SimilarityContains 1 patatin domain. {ECO:0000305}.
SimilarityContains 2 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15044461}; Multi- pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15044461}.