LMPD Database

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LMP007206

UniProt Annotations

Entry Information
Gene NameAAA family ATPase VPS4
Protein EntryVPS4_YEAST
UniProt IDP52917
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionInvolved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. {ECO:0000269|PubMed:11329380, ECO:0000269|PubMed:9155008, ECO:0000269|PubMed:9606181}.
InteractionP39929:SNF7; NbExp=4; IntAct=EBI-20475, EBI-17554; Q04272:VPS20; NbExp=6; IntAct=EBI-20475, EBI-28157; Q06263:VTA1; NbExp=7; IntAct=EBI-20475, EBI-37098;
MiscellaneousPresent with 5350 molecules/cell in log phase SD medium
MiscellaneousPresent with 5350 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the AAA ATPase family
SimilarityBelongs to the AAA ATPase family. {ECO:0000305}.
SimilarityContains 1 MIT domain
SimilarityContains 1 MIT domain. {ECO:0000305}.
Subcellular LocationEndosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Subcellular LocationEndosome membrane ; Peripheral membrane protein .
SubunitMonomer or homodimer (in nucleotide-free form). Decamer, dodecamer or tetradecamer of two stacked respective homooligomeric rings (when bound to ATP); the dodecameric form seems to be predominant. Interacts with VPS20. Interacts with VTA1; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex. Interacts with DID2. Interacts with DID4. Interacts with IST1; IST1 competes with VTA1 for binding with VPS4. {ECO:0000269|PubMed:12953057, ECO:0000269|PubMed:15086794, ECO:0000269|PubMed:16505166, ECO:0000269|PubMed:16601096, ECO:0000269|PubMed:17130288, ECO:0000269|PubMed:17928861, ECO:0000269|PubMed:17949747, ECO:0000269|PubMed:18032584, ECO:0000269|PubMed:18280501, ECO:0000269|PubMed:9606181}.